منابع مشابه
Mechanotransduction and flow across the endothelial glycocalyx.
In this inaugural paper, we shall provide an overview of the endothelial surface layer or glycocalyx in several roles: as a transport barrier, as a porous hydrodynamic interface in the motion of red and white cells in microvessels, and as a mechanotransducer of fluid shearing stresses to the actin cortical cytoskeleton of the endothelial cell. These functions will be examined from a new perspec...
متن کاملDragging along: the glycocalyx and vascular endothelial cell mechanotransduction.
The glycocalyx is a complex and highly dynamic polymeric meshwork that coats the surfaces of most cells and consists of proteoglycans, glycosaminoglycans (GAGs), and glycoproteins, as well as adherent plasma proteins.1,2 In the microvasculature, the glycocalyx layer on the endothelial cell surface plays a critical role in regulating vessel permeability, modulating the dynamics of near-wall move...
متن کاملLung heparan sulfates modulate K(fc) during increased vascular pressure: evidence for glycocalyx-mediated mechanotransduction.
Lung endothelial cells respond to changes in vascular pressure through mechanotransduction pathways that alter barrier function via non-Starling mechanism(s). Components of the endothelial glycocalyx have been shown to participate in mechanotransduction in vitro and in systemic vessels, but the glycocalyx's role in mechanosensing and pulmonary barrier function has not been characterized. Mechan...
متن کاملThe endothelial glycocalyx
Once thought to be a structure of small size and uncertain significance, the endothelial glycocalyx is now known to be an important regulator of endothelial function. Studies of the systemic vasculature have demonstrated that the glycocalyx forms a substantial in vivo endothelial surface layer (ESL) critical to inflammation, barrier function, and mechanotransduction. The pulmonary ESL is signif...
متن کاملMechanotransduction through the cytoskeleton.
We constructed a model cytoskeleton to investigate the proposal that this interconnected filamentous structure can act as a mechano- and signal transducer. The model cytoskeleton is composed of rigid rods representing actin filaments, which are connected with springs representing cross-linker molecules. The entire mesh is placed in viscous cytoplasm. The model eukaryotic cell is submitted to ei...
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ژورنال
عنوان ژورنال: Journal of Internal Medicine
سال: 2006
ISSN: 0954-6820,1365-2796
DOI: 10.1111/j.1365-2796.2006.01620.x